Plenary Paper In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells
نویسندگان
چکیده
1Harvard Medical School, Boston, MA; 2Harvard Stem Cell Institute, Boston, MA; 3Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA; 4Department of Laboratory Medicine, Joint Program in Transfusion Medicine, Children’s Hospital, Boston, MA; 5Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; and 6Cancer Science Institute, National University of Singapore, Singapore
منابع مشابه
Specification of Hemato-Endothelial-Like Structures and Generation of Hematopoietic Progenitor Cells from Human Pluripotent Stem Cells
Background and purpose: Human pluripotent stem cells (hPSCs) with the ability to differentiate into adult cells have provided a new perspective for treatment of some diseases. But, the efficiency of differentiation methods to generate hematopoietic progenitor cells (HPCs) is faced with multiple challenges. In the present study, we investigated the formation of hemato-endothelial-like structure...
متن کاملInduced pluripotent stem cells (iPSCs) based approaches for hematopoietic cancer therapy
Induced pluripotent stem cells (iPSCs) are reprogrammed from somatic cells through numerous transcription factors. Human induced pluripotent stem cell approaches are developing as a hopeful strategy to improve our knowledge of genetic association studies and the underlying molecular mechanisms. Rapid progression in stem cell therapy and cell reprogramming provides compelling reasons for its fe...
متن کاملIn vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
Lineage-restricted cells can be reprogrammed to a pluripotent state known as induced pluripotent stem (iPS) cells through overexpression of 4 transcription factors. iPS cells are similar to human embryonic stem (hES) cells and have the same ability to generate all the cells of the human body, including blood cells. However, this process is extremely inefficient and to date has been unsuccessful...
متن کاملLarge-Scale Expansion of Human Embryonic and Induced Pluripotent Stem Cells for Cell Therapy Applications
Successful isolation, derivation and culturing of human pluripotent stem cells, including human embryonic stem cells (hESCs) and human induced pluripotent stem (hiPSCs) cells in laboratory scale has opened new horizones for cell therapy applications such as tissue engineering and regenerative medicine. However, most of the cell therapy protocols using these unique cells require large number of ...
متن کاملA synthetic three-dimensional niche system facilitates generation of functional hematopoietic cells from human-induced pluripotent stem cells
BACKGROUND The efficient generation of hematopoietic stem cells (HSCs) from human-induced pluripotent stem cells (iPSCs) holds great promise in personalized transplantation therapies. However, the derivation of functional and transplantable HSCs from iPSCs has had very limited success thus far. METHODS We developed a synthetic 3D hematopoietic niche system comprising nanofibers seeded with bo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013